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Papers and books

Past research presentations and awards are listed here.

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2025

Design of a thermostable bilirubin oxidase from Myrothecium verrucaria
Haruka Horiguchi, Kado Yamada, Shohei Semba, Hironori Tsuboi, Takayuki Bogaki, Akio Koda, Kazuhiko Ishikawa, Yutaro Mori, Ogino Chiaki, Takagi Masahiro, Yoshio Tsujino
J. Biosci. Bioeng.
140(2):59-65

2024

Bilirubin oxidase expression and activity enhancement from Myrothecium verrucaria in Aspergillus species
Haruka Horiguchi, Kado Semba, Hironori Yamada, Hirokazu Tsuboi, Takayuki Bogaki, Akio Koda, Kataoka Kunishige, Takagi Masahiro, Yoshio Tsujino
J. Biosci. Bioeng.
138(3):212-217
Development of cosmetics using ingredients derived from sake
Hiroyuki Yamada, Yuki Oura, Akio Koda, Kenji Ozeki
Cosmetic Stage
68-75
The effects of ethyl α-D-glucoside-containing beverage intake on skin elasticity in healthy subjects: A randomized, placebo-controlled, double-blind, parallel-group comparative study
Hiroyuki Yamada, Shinsuke Nerume, Yuki Oura, Takayuki Bogaki, Akio Koda, Naoko Suzuki, Tatsuya Izumi
Pharmacology and treatment
52(2):167-185

2023

Mechanisms of production and control of acetate esters in yeasts
Hiroyuki Yoshimoto, Takayuki Bogaki
J. Biosci. Bioeng.
136(4):261-269
About "J-Premier Extract 31," a natural ingredient from a sake brewery
Hiroyuki Yamada, Yuki Oura, Akio Koda
Development and Market of Fermented Cosmetics (CMC Publishing)
23-29

2022

Recombinant protein production using Aspergillus oryzae
Hirokazu Tsuboi, Yu Kato, Akio Koda
Bioprocessing technology for the production of useful substances
496-503
About "J-Premier Extract 31," a natural ingredient made using sake and fermentation technology
Hiroyuki Yamada, Yuki Oura, Akio Koda
Bioindustry
39(2):12-18

2021

Homogalacturonan and xylogalacturonan region specificity of self-cloning vector-expressed pectin methylesterase (AoPME1-3) in Aspergillus oryzae.
Hiroyuki Yamada, Shoko Kubo, Yuika Kunishige, Hotaru Azuma, Yuka Kotani, Satoshi Handa, Masami Nakazawa, Mitsuhiro Ueda, Yoshinori Hasegawa, Tatsuji Sakamoto
Enzyme and Microbial Technology
150:109894
Mass protein production system using koji mold
Akio Koda, Hirokazu Tsuboi, Takayuki Bogaki
Bioreactor scale-up and substance production case studies
311-317

2020

Protein contract production service from a sake brewery
Akio Koda, Kaoru Sakamoto, Shohei Yamada, Kazutoshi Hashimoto, Hiromasa Senba, Marie Kida, Kensuke Hata, Yu Kato, Hiroyuki Yamada, Hirokazu Tsuboi, Takayuki Bogaki
Journal of Bioengineering
98(12):706-708

2019

Development of Brewed Beverage Search System and Program
Yoichiro Kanno, Takeshi Onodera, Toyoaki Kamiya, Kiyoshi Toko
Sensors and Materials
31(7):2405-2413

2018

Development of a brewed alcohol search device and program
Yoichiro Kanno, Toyoaki Kamiya, Takeshi Onodera, 都甲潔
Journal of the Japanese Society of Taste and Smell Studies
20(3): S25-S28
Development of alcoholic beverages containing high amounts of ethyl .ALPHA.-D-glucoside and their moisturizing properties
Takayuki Bogaki, Kenji Ozeki
Journal of Japan Brewing Association
113(6):336-345
Visualization of Flavor of Sake by Sensory Evaluation and Statistical Method
Yoichiro Kanno, Toshitaka Minetoki, Takayuki Bogaki, Kiyoshi Toko
Sensors and Materials
30: 1197-1206

2017

The cutting edge of microbial expression systems: current status and challenges Development of a mass protein production system using Aspergillus oryzae
Hirokazu Tsuboi, Akio Koda, Toshiki Minetoki, Takayuki Bogaki
Journal of Bioengineering
95(11):659-661
Introduction to the special feature (The cutting edge of microbial expression systems: current status and challenges)
Akio Koda, Yoshiteru Hashimoto
Journal of Bioengineering
95(11):640
Visualizing the taste of sake using sensory evaluation and statistical methods
Yoichiro Kanno, Toshiki Minetoki, Takayuki Bogaki
The science of deliciousness and the forefront of business development (CMC Publishing)
404-409
Custom protein expression service using genetically modified silkworms
Hiroyuki Yamada, Kensuke Hata
アグリバイオ
1(6):714-715
Effects of ethyl-α-D-glucoside on human dermal fibroblasts
Takayuki Bogaki, Keiichi Mitani, Yuki Oura, Kenji Ozeki
Biosci. Biotechnol. Biochem.
81: 1706-1711
Anti-inflammatory effects of sake lees and fermented sake lees extracts on animal models of fatigue
Masanori Yamato, Keiji Kume, Yasuhisa Tamura, Asami Eguchi, Takada Kobi, Takayuki Bogaki, Yosuke Kataoka
Journal of the Japanese Society of Fatigue Research
13(1):75

2016

What is non-public open innovation?
Masato Hirotsune
Journal of Bioengineering
94(11):681
Production of moisturizing sake made from re-fermented sake lees containing high amounts of ethyl .ALPHA.-D-glucoside
Takayuki Bogaki, Kenji Ozeki
Journal of Bioengineering
94(10):594-600
Development of a mass protein production system using Aspergillus oryzae
Akio Koda, Hirokazu Tsuboi, Toshiki Minetoki, Takayuki Bogaki
Protein Science Society Archives
9: e084
Identification of a novel Penicillium chrysogenum rhamnogalacturonanrhamnohydrolase and the first report of a rhamnogalacturonanrhamnohydrolase gene
Shotaro Matsumoto, Hiroyuki Yamada, Yuika Kunishige, Shigeo Takenaka, Masami Nakazawa, Mitsuhiro Ueda, Tatsuji Sakamoto
Enzyme and Microbial Technology
98: 76-85
Effect of rice as a raw material on the efficiency of ethyl .ALPHA.-D-glucoside production by fermentation
Takayuki Bogaki, Junichi Sagara, Kenji Ozeki
Food and Clinical Nutrition (Web)
e2016:13-20
Development of functional ingredients and bio-business originating from sake breweries
Akio Koda and Takayuki Bogaki
Chemistry and Education
64(11):556-559

2015

New technology development and materials related to moisturizing: New functionality of α-ethyl glucoside materials related to moisturizing effects
Masato Hirotsune
Fragrance Journal
43(10):57-61
Cloning and functional analysis of fungal rhamnogalacturonan rhamnohydrolase (RGRH)
Shotaro Matsumoto, Hiroyuki Yamada, Masami Nakazawa, Mitsuhiro Ueda, Ryuji Sakamoto
Applied Glycoscience
5(3):52
Transglycosilation activity of Aspergillus oryzae-derived α-glucosidase.
E Nagayoshi, K Ozeki, M Hata, T Minetoki, Y Takii
J. Biol. Macromol.
15(1):13-27
Development of acrylamide-free coffee using koji mold
Kenji Ozeki, Takayuki Bogaki, Hirokazu Tsuboi, Kazuya Iwai, Nakagiri Osamu
The Frontline of Fermented and Brewed Foods (CMC Publishing)
206-217
Development of a method for producing sake with a high content of .ALPHA.-ethyl-D-glucoside and its moisturizing effect
Takayuki Bogaki, Junichi Sagara, Kenji Ozeki
Food and Clinical Nutrition (Web)
e2015:10-16

2014

Continued Basic Bioengineering Course Bio Talk The Changing World of Sake
Masato Hirotsune
Journal of Bioengineering
92(4):184-187
Changes in skin properties following oral ingestion of sake concentrate
Yuji Yamashita, Mai Yamazaki, Takeshi Takizawa, Yoshio Tsujino, Masato Hirotsune, Hachiro Tagami, Kazutami Sakamoto
Chiba University of Science Bulletin
7: 97-104
Functional properties of sake lees and product development that utilizes them
Toshiki Minetoki
Journal of Japan Brewing Association
109(1):11-20

2013

Production of biodiesel from plant oil hydrolysates using an Aspergillus oryzae whole-cell biocatalyst highly expressing Candida antarctica lipase B.
Adachi Daisuke, Hama Shinji, Kazunori Nakashima, Takayuki Bogaki, Ogino Chiaki, Akihiko Kondo
Bioresource Technology
135: 410-416
Commercializing Fermentation Technology: Looking Back on 30 Years of Research at a Sake Brewery
Masato Hirotsune
Journal of Japan Brewing Association
108(4):221-228
The definition of deliciousness
Yoichiro Kanno
Journal of Bioengineering
91(4):213
Harnessing the power of koji and brewing: The characteristics and uses of enzyme-treated sake lees seasoning
Toshiki Minetoki
Monthly Food Chemical
29(1):39-46

2012

Promoter analysis of the Aspergillus oryzae amylase gene and its application
Toshiki Minetoki, Akio Koda, Takayuki Bogaki
Revised edition: Molecular Koji Mycelium Biology (Sake Brewing Society of Japan)
80-90
"Profiber" is a new functional material made from sake lees
Toshiki Minetoki
Monthly Food Factory Manager
16(6):36-37

2011

Sake lees resistant protein
Toshiro Watanabe, Masato Hirotsune
Latest Technology and Functionality of Fermented and Brewed Foods II (CMC Publishing)
200-209
Nutritional Values ​​and Functionality of Amazake
Masato Hirotsune
Latest Technology and Functionality of Fermented and Brewed Foods II (CMC Publishing)
210-213
Production of useful proteins using a koji mold protein overexpression system
Akio Koda and Takayuki Bogaki
Latest Technology and Functionality of Fermented and Brewed Foods II (CMC Publishing)
257-266
High production of lipase using the Aspergillus oryzae protein expression system
Junpei Wada, Masato Hirotsune
Journal of Japan Brewing Association
106(6):336-341
Highly efficient biodiesel production by a whole-cell biocatalyst employing a system with high lipase expression in Aspergillus oryzae.
Takaya Tomohiro, Koda Risa, Adachi Daisuke, Kazunori Nakashima, Junpei Wada, Takayuki Bogaki, Ogino Chiaki, Akihiko Kondo
Appl Microbiol Biotechnol
90(3):1171-1177

2009

Production and properties of indigestible ingredients made from sake lees
Masayuki Yukawa, Daisuke Ito, Toshiki Minetoki, Toshiro Watanabe, Masato Hirotsune
Journal of Japan Brewing Association
104(12):963-968

2008

Effects of α-ethyl glucoside, a sake concentrate, on chronic alcoholic liver injury in mice
Hanae Izu, Kazuhisa Hizume, Kuniyasu Goto, Masato Hirotsune
Journal of Japan Brewing Association
103(8):646-652
Formation and Function of α-Ethyl Glucoside in Sake Brewing
Masato Hirotsune
Manufacturing with Microorganisms (CMC Publishing)
54-59

2007

A new ingredient developed using a two-stage fermentation method to combat metabolic syndrome: "Sake lees indigestible component"
Toshiro Watanabe, Toshiki Minetoki, Hiroyuki Tomotake, Norihisa Kato
FOOD Style21
11(12):51-54

2006

Humans, yeast, and bad amino acids
Takayuki Bogaki
Journal of Bioengineering
84(11): p457
The functionality of "ethyl α-D-glucoside" contained in sake
Masato Hirotsune
Latest Technology and Functionality of Fermented and Brewed Foods (CMC Publishing)
276-282
5′ Untranslated region of the Hsp12 gene contributes to efficient translation in Aspergillus oryzae.
A. Koda, T. Bogaki, T. Minetoki, M. Hirotsune
Appl Microbiol Biotechnol
70(3):333-336

2005

Genome sequencing and analysis of Aspergillus oryzae
Machida M, Asai K, Sano M, Tanaka T, Kumagai T, Terai G, Kusumoto K, Arima T, Akita O, Kashiwagi Y, Abe K, Gomi K, Horiuchi H, Kitamoto K, Kobayashi T, Takeuchi M, Denning DW, Galagan JE, Nierman W.C., Yu J, Archer DB, Bennett JW, Bhatnagar D, Cleveland TE, Fedorova ND, Gotoh O, Horikawa H, Hosoyama A, Ichinomiya M, Igarashi R, Iwashita K, Juvvadi PR, Kato M, Kato Y, Kin T, Kokubun A, Maeda H, Maeyama N, Maruyama J, Nagasaki H, Nakajima T, Oda K, Okada K, Paulsen I, Sakamoto K, Sawano T, Takahashi M, Takase K, Terabayashi Y, Wortman JR, Yamada O, Yamagata Y, Anazawa H, Hata Y, Koide Y, Komori T, Koyama Y, Minetoki T, Suharnan S, Tanaka A, Isono K, Kuhara S, Ogasawara N, Kikuchi H
Nature
438: 1157-1161
Taste, functionality and food material technology of rice. II. Development of functional material manufacturing technology from red bran.
Masayuki Yukawa, Kenji Ozeki
food industry
48(24):66-71
High expression of a synthetic gene encoding potato alpha-glucan phosphorylase in Aspergillus niger.
A. Koda, T. Bogaki, T. Minetoki, M. Hirotsune
J. Biosci. Bioeng.
100(5):531-537
Improving the efficiency of heterologous protein production by improving post-transcriptional processes
Akio Koda, Masafumi Tokuoka, Katsuya Gomi
Bioscience and Industry
63(8):543-546
The forefront of post-genomic research on Aspergillus oryzae: Development of a mass protein production system using Aspergillus oryzae
Akio Koda, Toshiki Minetoki
Journal of Bioengineering
83(6):295-297
Yeast breeding that suppresses morning sickness odor
Hirokazu Tsuboi
Journal of Bioengineering
83(5):247
Expression of the Fusarium oxysporum lactonase gene in Aspergillus oryzae: molecular properties of the recombinant enzyme and its application.
Honda, H Tsuboi, T Minetoki, H Nose, K Sakamoto, M Kataokao, S Shimizu
appl. Microbiol. Biotechnol.
66(5):520-526
Improvement of enolase promoter (P-enoA) by introduction of cis-element (region III) in Aspergillus oryzae
H Tsuboi, A Koda, T Toda, T Minetoki, M Hirotsune, M Machida
Biosci. Biotechnol. Biochem.
69(1):206-208

2004

Translation efficiency mediated by the 5′ untranslated region greatly affects protein production in Aspergillus oryzae.
A. Koda, T. Minetoki, K. Ozeki, M. Hirotsune
appl. Microbiol. Biotechnol.
66(3):291-296
New functionality of α-ethyl glucoside contained in sake
Masato Hirotsune
Journal of Japan Brewing Association
99(12):836-841
Analysis of the pyruvate transport system gene (JEN1) in a glucose-derepressed mutant isolated from a 2-deoxyglucose-resistant mutant and its application to sake brewing
Hirokazu Tsuboi, Yasushi Wakisaka, Masato Hirotsune, Ken Akao, 山田修, Osamu Akita
Journal of the Agricultural Chemistry Society of Japan
78(10):994-995
Development of low-alcohol sake
Masato Hirotsune
Warm old knowledge new
41: 58-62
The diverse roles of mRNA are emerging - Post-transcriptional regulation for substance production -
Akio Koda
Journal of Bioengineering
82(2):69

2003

Development of high expression system with the improved promoter using the cis-acting element in Aspergillus species.
Minetoki T, Tsuboi H, Koda A, Ozeki K
J. Biol. Macromol.
3(3):89-96
Promoter analysis of the amylase gene from sake koji mold
Toshiki Minetoki, Katsuhiko Kitamoto
Molecular Koji Mycelium Biology (The Brewing Society of Japan)
41-49
Analysis of the Pyruvate Permease Gene (JEN1) in Glucose Derepression Yeast (Saccharomyces cerevisiae) Isolated from a 2-Deoxyglucose-tolerant Mutant, and Its Application to Sake Making
H Tsuboi, Y Wakisaka, M Hirotsune, T Akao, O Yamada, O Akita
Biosci. Biotechnol. Biochem.
67(4):765-771

2002

Mold (II Biotechnology) Chapter 2 Protein Production
Toshiki Minetoki
Fundamental Science and Biotechnology of Mushrooms and Fungi (IPC)
529-538
Cloning, nucleotide sequencing, and expression of the β-galactosidase-encoding gene (lacA) from Aspergillus oryzae.
Yoshiyuki Ito, Takashi Sasaki, Katsuhiko Kitamoto, Chieko Kumagai, Kohjiro Takahashi, Katsuya Gomi, Gakuzo Tamura
J. Gen. Appl. Microbiol.
48(3):135-142
Continuous clarification of sake using enzymatic methods
Fuminori Seki, Kazuhiko Obuchi, Masato Hirotsune, Masaaki Hamaji, and Chieko Kumagai
Journal of Japan Brewing Association
97(1):81-86

2001

Deletion analysis of the enolase gene (enoA) promoter from the filamentous fungus Aspegillus oryzae.
Tomomi Toda, Motoaki Sano, Munechika Honda, Omar Rimoldi, Yong Yang, Midori Yamamoto, Kumiko Takase, Hirozumi Katsuro, Katsuhiko Kitamoto, Toshitaka Minetoki, Katsuya Gomi, Masayuki Machida
Curr. Genet.
40(4):260-267
Isolation of a New Lytic Enzyme for Hiochi Bacteria and Other Lactic Acid Bacteria.
Kazuhiko Obuchi, Kazuya Hasegawa, Masaaki Hamaji, Kenji Ozeki, Chieko Kumagai
J. Biosci. Bioeng.
91(5):487-492
Elucidation of the mechanism controlling acetate ester production in yeast
Hiroyuki Yoshimoto, Daisuke Fujiwara, Takayuki Bogaki, Nao Nagasawa, 藤井敏雄
Journal of Bioengineering
79(2):33-40

2000

Gene expression systems in eukaryotic microorganisms: Heterologous gene expression systems in the Aspergillus genus
Toshiki Minetoki
Chemistry and Biology
38(12):831-838
Rapid Detection of Homologously Integrated DNA Fragments and Accurate Quantitation of Their Copy Number in Transgenic Aspergillus oryzae by PCR.
Honda, T Minetoki, K Gomi, M Machida
J. Biosci. Bioeng.
90(5):577-579
Promoter analysis of the amylase gene from sake koji mold
Toshiki Minetoki, Katsuhiko Kitamoto
Journal of Japan Brewing Association
95(8):560-568
Molecular Cloning and Characterization of a Transcriptional Activator Gene, amyR, Involved in the Amylolytic Gene Expression in Aspergillus oryzae.
K Gomi, T Akeno, T Minetoki, K Ozeki, C Kumagai, N Okazaki, Y Iimura
Biosci. Biotechnol. Biochem.
64(4):816-827

1999

A method for breeding black koji mold that produces thousands of times more useful enzymes
Kenji Ozeki, Toshiki Minetoki
Bioscience and Industry
57(6):397-398
Molecular and enzymic properties of recombinant 1,2-α-mannosidase from Aspergillus saitoi overexpressed in Aspergillus oryzae cells.
E Ichishima, N Taya, M Ikeguchi, Y Chiba, M. Nakamura, C Kawabata, T. Inoue, K Takahashi, T Minetoki, K Ozeki, C Kumagai, K Gomi, T Yoshida, T Nakajima
Biochem. J.
339(3):589-597
Protoplast formation and regeneration of various yeasts using cell wall lytic enzymes produced by Streptomyces rochei DB-34
Kazuhiko Ohbuchi, Akiko Nishi, Masaaki Hamaji, and Chieko Kumagai
Journal of Bioengineering
77(4):137-146
Isolation and Characterization of the ATF2 Gene Encoding Alcohol Acetyltransferase II in the Bottom Fermenting Yeast Saccharomyces pastorianus.
H. Yoshimoto, D Fujiwara, T Momma, K Tanaka, H Sone, N. Nagasawa, Y Tamai
Yeast
15(5):409-417
Isolation of a constitutively producing mutant of Streptomyces rochei PHA-34 strain producing Phaffia cell wall lytic enzyme and extraction of astaxanthin using the enzyme
Akiko Nishi, Kazuhiko Obuchi, Masaaki Hamaji, Chieko Kumagai
Journal of Bioengineering
77(2):60-65

1998

Cloning and Nucleotide Sequence of the Alcohol Acetyltransferase II Gene (ATF2) from Saccharomyces cerevisiae Kyokai No. 7.
N Nagasawa, T Bogaki, A Iwamatsu, M Hamachi, C Kumagai
Biosci. Biotechnol. Biochem.
62(10):1852-1857
Purification and Characterization of a Feruloylesterase from Aspergillus awamori.
T Koseki, S Furuse, K Iwano, H. Matsuzawa
Biosci. Biotechnol. Biochem.
62(10):2032-2034
Improvement of promoter activity by the introduction of multiple copies of the conserved region III sequence, involved in the efficient expression of Aspergillus oryzae amylase-encoding genes.
T Minetoki, C Kumagai, K Gomi, K Kitamoto, K Takahashi
appl. Microbiol. Biotechnol.
50(4):459-467
Breeding of koji mold producing thermostable α-amylase derived from Bacillus licheniformis and its use in liquefaction mashing
Kenji Ozeki, Akio Koda, Toshiki Minetoki, Masaaki Hamaji, and Chieko Kumagai
Journal of Bioengineering
76(7):301-307
Development of a method for efficient transformation of koji mold (Aspergillus oryzae)
Kenji Ozeki, Yoko Nagamasu, Akio Koda, Toshiki Minetoki, Kazuhiko Obuchi, Masaaki Hamaji, and Chieko Kumagai
Journal of Bioengineering
76(5):187-193
Studies on the analysis of Aspergillus oryzae gene promoters and transformation methods
Kenji Ozeki
Nada Sake Research Association Newsletter
-
Continuous sake brewing using a bioreactor
Masato Hirotsune
Nada Sake Research Association Newsletter
-

1997

Development of a high-level expression system in filamentous fungi using an improved promoter utilizing a conserved sequence (Region III)
Toshiki Minetoki
Bioindustry
14(11):30-39
Recent advances in molecular biological analysis of Aspergillus oryzae (A. oryzae) Functions of Koji in Sake Brewing and Genetic Analysis
Toshiki Minetoki, Katsuhiko Kitamoto
Journal of the Agricultural Chemistry Society of Japan
71(10):1018-1023
An Aspergillus awamori acetylesterase: Purification of the enzyme, and cloning and sequencing of the gene.
T Koseki, S Furuse, K Iwano, H Sakai, H. Matsuzawa
Biochem. J.
326(2):485-490
Screening of lytic enzymes for red yeast Phaffia rhodozyma cell walls and extraction of astaxanthin
Yoshida Mitsuko, Nishi Akiko, Obuchi Kazuhiko, Hojo Tomoko, Matsuzawa Akihito, Hamaji Masaaki, Kumagai Chieko
Journal of Bioengineering
75(4):229-238
Rapid and Sensitive Detection of Hiochi Bacteria by Amplification of Hiochi Bacterial Common Antigen Gene by PCR Method and Characterization of the Antigen.
J Nakamura, D Ito, K Nagai, Y Umehara, M Hamachi, C Kumagai
J. Ferment. Bioeng.
83(2):161-167
Functions of koji in sake brewing and genetic analysis
Toshiki Minetoki, Katsuhiko Kitamoto
Journal of the Agricultural Chemistry Society of Japan
71(10):1018-1023

1996

Deletion analysis of promoter elements of the Aspergillus oryzae agdA gene encoding α-glucosidase.
T Minetoki, Y Nunokawa, K Gomi, K Kitamoto, C Kumagai, G Tamura
Current. Genetics.
30(5):432-438
Rapid detection method for hiochi bacteria
Masaaki Hamaji
Bioscience and Industry
54(10):729-730
Nucleotide Sequences of Alcohol Acetyltransferase Genes from Lager Brewing Yeast, Saccharomyces carlsbergensis.
T Fujii, H. Yoshimoto, N Nagasawa, T Bogaki, Y Tamai, M Hamachi
Yeast
12(6):593-598
Professional & Consulting Engineers and Biotechnology Part 9: The Relationship between Bioprocesses, Artificial Intelligence, and Artificial Life
Kazuo Matsuura
Bioindustry
13(5):47-53
Screening of fungal cell wall lytic enzymes and their potential as fungicides
Tomoko Hojo, Kazuhiko Obuchi, Masaaki Hamaji
Antibacterial and antifungal
24(4):263-268
Construction of a Promoter Probe Vector Autonomously Maintained in Aspergillus and Characterization of Promoter Regions Derived from A. niger and A. oryzae Genomes.
K Ozeki, A Kanda, M Hamachi, Y Nunokawa
Biosci. Biotechnol. Biochem.
60(3):383-389
Immunochemical classification of hiochi bacteria using specific monoclonal antibodies and analysis of cell surface antigens recognized by the antibodies
Jinshichiro Nakamura, Mayumi Iwata (Minami), Masaaki Hamaji
Journal of Bioengineering
74(2):83-90
Alcohol Dehydrogenase I of Sake Yeast Saccharomyces cerevisiae Kyokai No.7.
K Ohbuchi, Y Ishikawa, A Kanda, M Hamachi, Y Nunokawa
J. Ferment. Bioeng.
81(2):125-132
Vitamin C production by koji mold and its transfer to sake
Yoko Nagamasu, Kenji Ozeki, Akiyoshi Kanda, Masaaki Hamaji, Chieko Kumagai, Yataro Nunokawa
Journal of Bioengineering
74(1):1-6

1995

Characteristic Expression of Three Amylase-encoding Genes, agdA, amyB, and glaA in Aspergillus oryzae Transformants Containing Multiple Copies of the agdA Gene.
T Minetoki, K Gomi, K. Kitamoto, C Kumagai, G Tamura
Biosci. Biotechnol. Biochem.
59(12):2251-2254
A Specific Method for the Detection of Hiochi Bacteria Using an Enzyme-linked Immunosorbent Assay System with Anti-hiochi Bacteria Monoclonal Antibodies.
Nakamura J, Minami M, Doi K, Hamachi M
Biosci. Biotechnol. Biochem.
59(11):2039-2043
Measurement and Control of Bioprocesses (4) Future Prospects of Neural Network Applications
Kazuo Matsuura
Bioscience and Industry
53(11):956-959
Optimizing Control of Sensory Evaluation in the Sake Mashing Process by Decentralized Learning of Fuzzy Inferences Using a Genetic Algorithm.
K Matsuura, H Shiba, M Hirotsune, M Hamachi
J. Ferment. Bioeng.
80(3):251-258
Nucleotide Sequence and Expression of α-Glucosidase-encoding Gene (agdA) from Aspergillus oryzae.
T Minetoki, K Gomi, K Kitamoto, C Kumagai, G Tamura
Biosci. Biotechnol. Biochem.
59(8):1516-1521
A Method for the Re-isolation of an Autonomously Replicating Plasmid from Aspergillus Transformants.
K Ozeki, K Hizume, A Kanda, M Hamachi, Y Nunokawa
Biosci. Biotechnol. Biochem.
59(6):113-1134
New Separation Technique under Normal Temperature and Pressure Using an Ultrasonic Atomization.
K Matsuura, M Kobayashi, M Hirotsune, M. Sato, H Sasaki, K Shimizu
Chemical Engineering Symposium Series
46: 44-49
The Science of Sake: Ginjo Sake among Refined Sake
Chieko Kumagai
生物の科学 遺伝
49(1):25-30
Modeling of the Sensory Evaluation of Sake by Dempster-Shafer's Measure and Genetic Algorithm.
K Matsuura, M Hirotsune, M Hamachi, Y Nunokawa
J. Ferment. Bioeng.
79(1):45-53
Special Feature: Control in Biosystems. Control in Sake Brewing.
Kazuo Matsuura
Measurement and Control
34(1):53-57

1994

Transformation of Intact Aspergillus niger by Electroporation.
K Ozeki, F Kyoya, K Hizume, A Kanda, M Hamachi, Y Nunokawa
Biosci. Biotechnol. Biochem.
58(12):2224-2227
On-line control of sake fermentation process by fermentation rate trajectory control
Kazuo Matsuura, Masato Hirotsune, Masaaki Hamaji
Journal of Bioengineering
72(6):453-460
Molecular Cloning, Sequence Analysis, and Expression of the Yeast Alcohol Acetyltransferase Gene.
T Fujii, N. Nagasawa, A Iwamatsu, T Bogaki, Y Tamai, M Hamachi
Appl. Environ. Microbiol.
60(8):2786-2792
Special Feature: Bioprocess Control. Artificial Intelligence Control in Sake Brewing.
Kazuo Matsuura
Chemical Engineering
39(4):310-315
Alcohol dehydrogenase (ADH) of sake yeast
Kazuhiko Obuchi, Yukiko Ishikawa, Akiyoshi Kanda, Masaaki Hamaji, Yataro Nunokawa
Journal of the Agricultural Chemistry Society of Japan
68(3):451
Acceleration of Cell Growth and Ester Formation by Ultrasonic Wave Irradiation.
K Matsuura, M Hirotsune, Y Nunokawa, M. Sato, Honda
J. Ferment. Bioeng.
77(1):36-40
Development of continuous sake brewing method using bioreactors
Masato Hirotsune, Kazuo Matsuura, Masaaki Hamaji
Journal of Bioengineering
72(1):21-31
Use of ultrasound in alcoholic beverage brewing
Kazuo Matsuura
Journal of Japan Brewing Association
89(1):13-17

1993

The Purification, Properties and Internal Peptide Sequences of Alcohol Acetyltransferase Isolated from Saccharomyces cerevisiae Kyokai No. 7.
T Minetoki, T Bogaki, A Iwamatsu, T Fujii, M Hamachi
Biosci. Biotechnol. Biochem.
57(12):2094-2098
A familiar bio-product: A new way of brewing sake
Yataro Nunokawa
Chemical
48(10):669-671
Online control of continuous sake fermentation
Kazuo Matsuura
Journal of Japan Brewing Association
88(5):344-348
Effect of adding solid additives on yeast growth
Michiyo Takezaki, Kazuo Matsuura, Masato Hirotsune, Masaaki Hamaji
Journal of Japan Brewing Association
88(4):319-325
Manufacturing method for glutathione-containing sake
Yasuharu Sawano, Fumiko Fujii, Akiyoshi Kanda, Masaaki Hamaji
Journal of Japan Brewing Association
88(2):163-164

1992

A simple method for measuring koji fungus mass using commercially available enzyme preparations
Fumiko Fujii, Kenji Ozeki, Akiyoshi Kanda, Masaaki Hamaji, Yataro Nunokawa
Journal of Japan Brewing Association
87(10):757-759
Thermal Control Strategy for Isoamylacetate Formation in Sake Brewed with a Saccharified Rice Solution.
A Matsuura, M Hirotsune, M Hamachi, Y Nunokawa
J. Ferment. Bioeng.
74(2):112-116
Isolation of sake yeast with high ester production
Akiyoshi Kanda
Research on Sake Yeast: Research in the 80s (Sake Yeast Research Society)
124
Development of glutathione-containing yeast
Yasuharu Sawano
Research on Sake Yeast: Research in the 80s (Sake Yeast Research Society)
128-133
AATFase: Purification and properties of ATFase.
Toshiki Minetoki
Research on Sake Yeast: Research in the 80s (Sake Yeast Research Society)
140-145
Use of bioreactors
Masato Hirotsune
Research on Sake Yeast: Research in the 80s (Sake Yeast Research Society)
175-181
Alcohol acetyltransferase in sake yeast
Toshiki Minetoki
Journal of Japan Brewing Association
87(5):334-340
Studies on Continuous Sake Brewing (Part 5) Continuous Sake Brewing Using a Multistage Horizontal Flow Bioreactor
Kazuo Matsuura, Masato Hirotsune, Masaaki Hamaji
Journal of Fermentation Technology
70(1):17-23

1991

Effect of adding monopotassium phosphate on the brewing of glutathione-containing sake
Fumiko Fujii, Yasuharu Sawano, Akiyoshi Kanda, Masaaki Hamaji
Journal of Fermentation Technology
69(4):233-236
Breeding of high glycerol-producing yeasts and sake brewing
Kazuhiko Obuchi, Akiyoshi Kanda, Masaaki Hamaji, Yataro Nunokawa
Journal of Fermentation Technology
69(4):203-209
Brewing glutathione-containing sake
Yasuharu Sawano
Journal of Japan Brewing Association
86(3):177-181

1989

Molecular cloning and nucleotide sequence of the gramicidin S synthetase 1 gene.
K Hori, Y Yamamoto, T Minetoki, T Kurotsu, M Kanda, S Miura, K. Okamura, J. Furuyama, Y Saito
Journal of Biochemistry
106(4):639-645
Studies on aroma formation by yeast. V. Effect of aroma-stimulating substances on the filtrate-fermented sake using synthetic sugar solution.
Fujio Nakata, Masaaki Hamaji, Takemitsu Honma
Journal of Fermentation Technology
67(5):411-417
Studies on aroma formation by yeast. IV. The role of aroma-stimulating substances in filtrate-fermented sake.
Fujio Nakata, Masaaki Hamaji, Takemitsu Honma
Journal of Fermentation Technology
67(5):403-409
Dry storage of rice koji
Kenji Ozeki
Journal of Japan Brewing Association
84(7):447-452
Drug resistance of Hiochi bacteria to various antibiotics
Kazuhiko Ohbuchi, Yuko Higashida, Akiyoshi Kanda, Masaaki Hamaji, Takemitsu Honma
Journal of Japan Brewing Association
84(4):270-272
Brewing sake with less urea by adding inorganic salts
Akiyoshi Kanda, Tomoko Mimori, Masaaki Hamaji, Takemitsu Honma
Journal of Japan Brewing Association
84(2):114-117

1988

The relationship between enzyme preparation and fermentation temperature of mash and the amount of urea produced
Yoshitsugu Yano, Masaaki Hamaji, Takemitsu Honma
Journal of Japan Brewing Association
83(10):709-712
Enzyme activity of koji and urea production in sake
Kenji Ozeki, Fujio Nakata, Masaaki Hamaji, Takemitsu Honma
Journal of Japan Brewing Association
83(9):610-613
Studies on the storage of dried koji. III. Practical brewing experiments using stored dried koji.
Kenji Ozeki, Tadayuki Yamamoto, Masaaki Hamaji, Takemitsu Honma
Journal of Japan Brewing Association
83(7):496-500
Studies on the storage of dried koji. I. Small-scale sake brewing experiments using stored dried koji.
Kenji Ozeki, Tadayuki Yamamoto, Masaaki Hamaji, Takemitsu Honma
Journal of Japan Brewing Association
83(2):131-135
Storage of dried koji. I. Quality changes during storage.
Kenji Ozeki, Tadayuki Yamamoto, Masaaki Hamaji, Takemitsu Honma
Journal of Japan Brewing Association
83(1):47-51
Substances that promote aroma formation in filtrate brewing
Fujio Nakata, Masaaki Hamaji, Takemitsu Honma
Journal of Fermentation Technology
66(1):17-23
One cause of high aromatic content in filtrate-brewed sake
Fujio Nakata, Masaaki Hamaji, Takemitsu Honma
Journal of Fermentation Technology
66(1):11-15

1987

Minor aroma components of sake The aroma of ginjo sake
Yataro Nunokawa
Science and Industry
61(6):227-234
Aroma formation during filtrate preparation
Fujio Nakata, Masaaki Hamaji, Takemitsu Honma
Journal of Fermentation Technology
65(3):179-184
Actual example of aseptic filling and packaging: Aseptic packaging technology for sake
Takemitsu Honma and Akiyoshi Kanda
Japan Food Science
26(7):70-80

1986

Studies on the room temperature aseptic filling of sake. V. Aseptic filling in paper containers (BIB type).
Akiyoshi Kanda, Masaaki Hamaji, Takemitsu Honma
Brewery Society of Japan Magazine
81(8):544-548
Studies on the aseptic filling of sake at room temperature. IV. Aseptic filling of sake in bottles.
Akiyoshi Kanda, Masaaki Hamaji, Takemitsu Honma
Brewery Society of Japan Magazine
81(7):481-484
Examination of sterile sake production methods
Akiyoshi Kanda, Masaaki Hamaji, Takemitsu Honma
Brewery Society of Japan Magazine
81(4):259-264
Sake brewing using enzymes
Yataro Nunokawa
microorganism
2(1):2-8

1985

Studies on the room temperature aseptic filling of sake. II. Microbial investigation of sake filling materials and examination of sterilization methods.
Akiyoshi Kanda, Masaaki Hamaji, Takemitsu Honma
Brewery Society of Japan Magazine
80(12):875-878
Aseptic filling of sake at room temperature. I. Environmental survey of sake product factories and examination of environmental disinfectants.
Akiyoshi Kanda, Masaaki Hamaji, Takemitsu Honma
Brewery Society of Japan Magazine
80(11) :p812-817

1984

Relationship between base content and sensory evaluation. I. Sake quality and nucleic acid-related substances.
Akiyoshi Kanda, Masaaki Hamaji, Takemitsu Honma
Journal of Fermentation Technology
62(6):415-420

1983

Microdetermination of glucose in sake and sake mash using a glucose meter
Yasuo Umehara, Kenji Kurima, Shosaku Takamori, Hisao Osawa
Brewery Society of Japan Magazine
78(1):75-76